For a fast, convenient way of getting from Václav Havel Airport Prague (PRG) to the city center, take the Airport Express bus (AE Express). Bus stops are located outside both Terminals 1 and 2. Buses run every 30 minutes to an hour, from 5:30 a.m. to 9 p.m.
In terms of getting around Prague, remember that the city center is compact and walkable (use taxis cautiously due to overcharging). For Prague Metro, trams and buses, your ticket or pass provides unlimited switching between the three.